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2025-04-25T20:06:31Z

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For the new study, the scientists performed trials with more than 700 young salmon, or “smolts,” in the laboratory and in the field. The research team used sound-transmitting tags to remotely track hundreds of smolts in 2020 and 2021 as the fish navigated the Dal River in central Sweden.

Migrating smolts swim downriver into a reservoir, hurtle over rapids and crest two dams before finally reaching the Baltic Sea. The journey takes 10 to 13 days.
Two major classes of pharmaceuticals — benzodiazepines and opioids — “are commonly detected in rivers and streams worldwide, including in Sweden, where our study was conducted,” Michelangeli said.

Time-release implants in the smolts dispensed two drugs from these classes: clobazam and tramadol. Fish received clobazam, or tramadol, or both. A control group of smolts received implants with no drugs in them at all.

“These two drugs are known to interact chemically when taken together in humans, and they often co-occur in the environment,” Michelangeli said. “This made them a good test case to explore how pharmaceutical mixtures might affect animal behaviour.”

Along with the field trials, the scientists ran a laboratory-based study on 256 smolts to confirm that the implants worked as intended and that the drugs were lingering in the fishes’ bodily tissues and brains.

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